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Insulin allergy and insulin resistance due to immune mechanisms are mediated by antibodies. The allergen may not be insulin, but protein (for example, protamine) and non-protein (for example, zinc) impurities that make up the drug. Prednisone pills in most cases, allergies are caused by itself or its polymers, as evidenced by local allergic reactions to human insulin and systemic reactions to highly purified insulins.
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The transient nature of early local allergic reactions, as well as insulin resistance after desensitization to insulin, may be due to blocking IgG. Local allergic reactions that develop 8-24 hours after insulin injection may be the result of an allergic reaction.and delayed type to insulin or prednisone 20 mg. Insulin resistance can be due to both immune and non-immune mechanisms. Non-immune mechanisms include obesity, ketoacidosis, endocrine disorders, infection. Insulin resistance due to immune mechanisms is very rare.
Allergic reactions to insulin can involve antibodies of different classes. Anaphylactic reactions, a significant proportion of early local allergic reactions, and possibly some late local allergic reactions are due to IgE. Local allergic reactions that develop 4-8 hours after insulin administration and insulin resistance are due to IgG.
It usually occurs during the first year of insulin treatment, develops over several weeks, and lasts from several days to several months. Sometimes insulin resistance occurs during desensitization to insulin.
Buy prednisone to insulin can be manifested by local and systemic reactions. They occur in 5-10% of patients. Mild local reactions develop more often. Over the past few years, the prevalence of allergic reactions to insulin has decreased significantly.
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Local allergic reactions (swelling, itching, pain) can be early and late. Early appear and disappear within 1 hour after injection, late - after a few hours (up to 24 hours). In some cases, the reaction is biphasic: its early manifestations last no more than 1 hour, then later, more persistent manifestations occur after 4-6 hours.